Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.
Identifieur interne : 002294 ( Main/Exploration ); précédent : 002293; suivant : 002295Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.
Auteurs : Haruka Nishimuta [Japon] ; Hisakazu Ohtani ; Masayuki Tsujimoto ; Kenichiro Ogura ; Akira Hiratsuka ; Yasufumi SawadaSource :
- Biopharmaceutics & drug disposition [ 0142-2782 ] ; 2007.
English descriptors
- KwdEn :
- Adrenergic beta-Agonists (metabolism), Arylsulfotransferase (drug effects), Arylsulfotransferase (metabolism), Beverages, Biflavonoids (pharmacology), Biological Availability, Catechin (analogs & derivatives), Catechin (pharmacology), Citrus paradisi (chemistry), Citrus sinensis (chemistry), Flavanones (pharmacology), Flavones (pharmacology), Herb-Drug Interactions, Humans, In Vitro Techniques, Phenols (pharmacology), Polyphenols, Quercetin (pharmacology), Sulfotransferases (drug effects), Sulfotransferases (metabolism), Tea (chemistry).
- MESH :
- chemical , analogs & derivatives : Catechin.
- chemical , chemistry : Tea.
- chemical , drug effects : Arylsulfotransferase, Sulfotransferases.
- chemical , metabolism : Adrenergic beta-Agonists, Arylsulfotransferase, Sulfotransferases.
- chemical , pharmacology : Biflavonoids, Catechin, Flavanones, Flavones, Phenols, Quercetin.
- chemistry : Citrus paradisi, Citrus sinensis.
- Beverages, Biological Availability, Herb-Drug Interactions, Humans, In Vitro Techniques, Polyphenols.
Abstract
Sulfotransferase (SULT) 1A1 and SULT1A3 play important roles in the presystemic inactivation of beta(2) agonists in the liver and intestine, respectively. The study aimed to investigate the inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3. The activities of both SULT1A1 and SULT1A3 were significantly inhibited by all the beverages investigated at a concentration of 10%. The beverage constituents were tested in concentration ranges considered to be physiologically relevant. The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3. The orange constituents, tangeretin and nobiletin, also completely inhibited SULT1A1. The tea constituents, (-)-epicatechin gallate and (-)-epigallocatechin gallate, both almost completely inhibited SULT1A1 and SULT1A3. Moreover, the theaflavin and thearubigin fractions of black tea both completely inhibited SULT1A1 and strongly inhibited SULT1A3. The inhibitory action of green tea on SULT1A3 was competitive, while that of black tea and oolong tea was mixed competitive/non-competitive. Mechanism-based inhibition was not observed with any beverage. In conclusion, various beverages, especially teas, inhibit the function of SULT1A3, and therefore may have the potential to increase the bioavailability of orally administered substrates of SULT1A3, such as beta(2) agonists.
DOI: 10.1002/bdd.579
PubMed: 17876860
Affiliations:
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Le document en format XML
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Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582</wicri:regionArea><orgName type="university">Université de Kyūshū</orgName><placeName><settlement type="city">Fukuoka</settlement><region type="province">Kyūshū</region><region type="prefecture">Préfecture de Fukuoka</region></placeName></affiliation></author><author><name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name></author><author><name sortKey="Tsujimoto, Masayuki" sort="Tsujimoto, Masayuki" uniqKey="Tsujimoto M" first="Masayuki" last="Tsujimoto">Masayuki Tsujimoto</name></author><author><name sortKey="Ogura, Kenichiro" sort="Ogura, Kenichiro" uniqKey="Ogura K" first="Kenichiro" last="Ogura">Kenichiro Ogura</name></author><author><name sortKey="Hiratsuka, Akira" sort="Hiratsuka, Akira" uniqKey="Hiratsuka A" first="Akira" last="Hiratsuka">Akira Hiratsuka</name></author><author><name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name></author></analytic><series><title level="j">Biopharmaceutics & drug disposition</title><idno type="ISSN">0142-2782</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic beta-Agonists (metabolism)</term><term>Arylsulfotransferase (drug effects)</term><term>Arylsulfotransferase (metabolism)</term><term>Beverages</term><term>Biflavonoids (pharmacology)</term><term>Biological Availability</term><term>Catechin (analogs & derivatives)</term><term>Catechin (pharmacology)</term><term>Citrus paradisi (chemistry)</term><term>Citrus sinensis (chemistry)</term><term>Flavanones (pharmacology)</term><term>Flavones (pharmacology)</term><term>Herb-Drug Interactions</term><term>Humans</term><term>In Vitro Techniques</term><term>Phenols (pharmacology)</term><term>Polyphenols</term><term>Quercetin (pharmacology)</term><term>Sulfotransferases (drug effects)</term><term>Sulfotransferases (metabolism)</term><term>Tea (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Catechin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Tea</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Arylsulfotransferase</term><term>Sulfotransferases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adrenergic beta-Agonists</term><term>Arylsulfotransferase</term><term>Sulfotransferases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Biflavonoids</term><term>Catechin</term><term>Flavanones</term><term>Flavones</term><term>Phenols</term><term>Quercetin</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus paradisi</term><term>Citrus sinensis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Beverages</term><term>Biological Availability</term><term>Herb-Drug Interactions</term><term>Humans</term><term>In Vitro Techniques</term><term>Polyphenols</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sulfotransferase (SULT) 1A1 and SULT1A3 play important roles in the presystemic inactivation of beta(2) agonists in the liver and intestine, respectively. The study aimed to investigate the inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3. The activities of both SULT1A1 and SULT1A3 were significantly inhibited by all the beverages investigated at a concentration of 10%. The beverage constituents were tested in concentration ranges considered to be physiologically relevant. The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3. The orange constituents, tangeretin and nobiletin, also completely inhibited SULT1A1. The tea constituents, (-)-epicatechin gallate and (-)-epigallocatechin gallate, both almost completely inhibited SULT1A1 and SULT1A3. Moreover, the theaflavin and thearubigin fractions of black tea both completely inhibited SULT1A1 and strongly inhibited SULT1A3. The inhibitory action of green tea on SULT1A3 was competitive, while that of black tea and oolong tea was mixed competitive/non-competitive. Mechanism-based inhibition was not observed with any beverage. In conclusion, various beverages, especially teas, inhibit the function of SULT1A3, and therefore may have the potential to increase the bioavailability of orally administered substrates of SULT1A3, such as beta(2) agonists.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Kyūshū</li><li>Préfecture de Fukuoka</li></region><settlement><li>Fukuoka</li></settlement><orgName><li>Université de Kyūshū</li></orgName></list><tree><noCountry><name sortKey="Hiratsuka, Akira" sort="Hiratsuka, Akira" uniqKey="Hiratsuka A" first="Akira" last="Hiratsuka">Akira Hiratsuka</name><name sortKey="Ogura, Kenichiro" sort="Ogura, Kenichiro" uniqKey="Ogura K" first="Kenichiro" last="Ogura">Kenichiro Ogura</name><name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name><name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name><name sortKey="Tsujimoto, Masayuki" sort="Tsujimoto, Masayuki" uniqKey="Tsujimoto M" first="Masayuki" last="Tsujimoto">Masayuki Tsujimoto</name></noCountry><country name="Japon"><region name="Kyūshū"><name sortKey="Nishimuta, Haruka" sort="Nishimuta, Haruka" uniqKey="Nishimuta H" first="Haruka" last="Nishimuta">Haruka Nishimuta</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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